Search our library of health articles, recipes, therapeutic diets and more

How America’s #1 Cooking Oil Causes Harmful Genetic Changes in Your Brain

How America’s #1 Cooking Oil Causes Harmful Genetic Changes in Your Brain

In 2019, Americans consumed 11 metric tons of soybean oil – making it the most widely-consumed edible oil in the United States. In fact, roughly 7 percent of the calories in the American diet come from soybean oil alone! The question:  Is soybean oil bad for your health? 

In short, yes.

For years, we’ve been told that “vegetable” oils are the healthier choice when it comes to cooking, baking and drizzling…

And unfortunately, too many Americans have listened to this misguided nutritional dogma. We have collectively removed the lard from our larders and replaced traditional fats like tallow and butter with “plant-based” oils, primarily made from soybeans, corn and canola.

But this dietary “oil change” from traditional animal fats to industrial plant-based oils comes with some and serious health consequences…

Today, you’ll discover how the drastic shift from animal fats to soybean oil has promoted the obesity and diabetes epidemics. You’ll also discover how it can negatively impact an important structure in the brain, called the hypothalamus, and modify genes that impair the healthy function of organs and hormones (including oxytocin – “the love hormone”).

In 2015, a group of researchers at University of California Riverside demonstrated that soybean oil consumption causes obesity, diabetes, insulin resistance and fatty liver in mice.  

The researchers state:

“The increase in obesity in the U.S. over the last half-century coincides with a shift in the dietary preference away from saturated fats from animal products and toward plant-based unsaturated fats. […] Our results show that soybean oil is able to induce these negative metabolic effects even in the context of coconut oil, which is rich in medium-chain triglycerides (MCTs) which have been shown to be anti-obesogenic, anti-inflammatory and insulin sensitizing. 1,2,3,4  

Given these results, the researchers wanted to learn more about the mechanisms behind the ability of soybean oil to manipulate our metabolism. So, in 2017, they conducted another study to see if soybean oil engineered to be low in linoleic acid produced the same results.

The researchers discovered that the lower linoleic acid soybean oil caused less obesity and insulin resistance… but it still induced fatty liver and promoted diabetes.5

Soybean Oil Scrambles Your Master Control Center and Changes 100+ Genes

Still curious, the same researchers conducted another study to compare the effects of three high-fat diets on mice: soybean oil, low linoleic soybean oil, and coconut oil.

They evaluated the brains of the mice and discovered that soybean oil cause profound effects on the hypothalamus – a small region of the brain that acts as a control center for regulating weight, body temperature, and metabolism.

They also discovered that soybean oil consumption changed the expression of over 100 genes involved in everything from inflammation and metabolism… to brain function and hormone production!6

One such gene was the OXT gene – which creates oxytocin – the “love” hormone. In the soybean-oil fed mice, levels of oxytocin in the hypothalamus went down. 

So, not only could soybean oil promote a host of chronic diseases… it may impact your ability to connect and bond with people!

In stark contrast, saturated-fat rich coconut oil produced very few changes in the hypothalamic genes.

Because these studies were performed in mice, the connection to humans isn’t directly correlated. However, the metabolic mechanisms are similar enough to make avoiding soybean oil a wise choice.

One of the lead authors of the study, cell biologist Dr. Poonamjot Deol, Ph.D. agrees: 

“If there’s one message I want people to take away, it’s this: Reduce consumption of soybean oil.” 

Choose Health-Promoting Traditional Fats

You probably already know that soybean oil is found in most conventional packaged foods – including sauces, dressings, baked and canned items. It is also one of the most common oils used for frying in restaurants. 

Avoiding conventional packaged foods and steering clear of fried foods at restaurants are two important steps you can take to keep soybean oil out of your body. 

For cooking, opt instead for natural fats – including pastured tallow, lard, duck fat, grass-fed butter and ghee, as well as coconut and avocado oils.

Your body – and your brain – will thank you!

How America’s #1 Cooking Oil Causes Harmful Genetic Changes in Your Brain – Healing Gourmet pin Save
References (6)
  1. Blasbalg TL, Hibbeln JR, Ramsden CE, Majchrzak SF, Rawlings RR. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr. 2011; 93: 950–962. 10.3945/ajcn.110.006643 (PubMed)
  2.  Nagao K, Yanagita T. Medium-chain fatty acids: functional lipids for the prevention and treatment of the metabolic syndrome. Pharmacol Res. 2010; 61: 208–212. 10.1016/j.phrs.2009.11.007 (PubMed)
  3. Dulloo AG. The search for compounds that stimulate thermogenesis in obesity management: from pharmaceuticals to functional food ingredients. Obes Rev. 2011; 12: 866–883. 10.1111/j.1467-789X.2011.00909.x (PubMed)
  4. Ogbolu DO, Oni AA, Daini OA, Oloko AP. In vitro antimicrobial properties of coconut oil on Candida species in Ibadan, Nigeria. J Med Food. 2007; 10: 384–387 (PubMed)
  5. Deol, P., Fahrmann, J., Yang, J. et al. Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. Sci Rep 7, 12488 (2017). https://doi.org/10.1038/s41598-017-12624-9 (PubMed)
  6. Poonamjot Deol, Elena Kozlova, Matthew Valdez, Catherine Ho, Ei-Wen Yang, Holly Richardson, Gwendolyn Gonzalez, Edward Truong, Jack Reid, Joseph Valdez, Jonathan R Deans, Jose Martinez-Lomeli, Jane R Evans, Tao Jiang, Frances M Sladek, Margarita C Curras-Collazo. Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice. Endocrinology, 2020;

This post may contain affiliate links. Click here to read my affiliate policy.

Kelley Herring

About the author

Kelley Herring

Kelley Herring, founder of Healing Gourmet, is a natural nutrition enthusiast with a background in biochemistry. Her passion is educating on how foods promote health and protect against disease and creating simple and delicious recipes for vibrant health and enjoyment.

Take Your Next Step Toward Better Health

Keto Baking Bundle

Gone keto but miss bread and dessert? Get 100+ foolproof recipes for grain-free breads and indulgent desserts that taste like the originals, without the sugar or the grains.

Get the Bundle

Instant Pot Keto

Want keto comfort food without the hours at the stove? Make 80+ quick, one-pot recipes that fit a busy week.

See the Recipes

GLP Gourmet

On a GLP-1 medication? Take the 60-second quiz to find your eating type and get 3 protein moves to protect your muscle.

Find My Type

Founding Member

Want it all in one place? Get every issue of Reinvented™ from The Kitchen Lab, plus a private 45-minute session with Kelley to build your personal plan. Only 25 spots.

Claim Your Spot

Not medical advice. Talk with your prescriber before changing your diet. Not affiliated with any medication brand.

Leave a Reply

Your email address will not be published. Required fields are marked *